Gigaxonin protein sequence
WebVery easy. Easy. Moderate. Difficult. Very difficult. Pronunciation of gigaxonin with 1 audio pronunciations. 0 rating. Record the pronunciation of this word in your own voice and … WebmRNA and Protein(s) NM_001377486.1 → NP_001364415.1 gigaxonin isoform 2. Status: REVIEWED. Source sequence(s) AC009148, AC092139 Conserved Domains (2) summary PHA03098 Location: 86 → 289 PHA03098; kelch-like protein; Provisional sd00038 … Add your description of the function of the gene or its protein product. Enter your e … A novel sequence alteration in the gene GAN, c.103G > T, was identified as …
Gigaxonin protein sequence
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WebDec 12, 2014 · p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells J Biol Chem. 2014 Dec 12;289 (50):34921 ... assays show that this modification is associated with the inhibition of NFκB interacting with its DNA binding sequences, leading to decreased expression of NFκB-transcribed ... WebAbstract. Gigaxonin, the product of GAN gene localized to chromosome 16, is associated with the early onset neuronal degeneration disease giant axonal neuropathy (GAN). …
WebBethyl Laboratories Anti-Gigaxonin Polyclonal, Catalog # A302-906A. Tested in Western Blot (WB) and Immunoprecipitation (IP) applications. ... Based on 100% sequence identity, this antibody is predicted to react with Mouse ... The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and ... WebWith the first genetic variant identified in the short ESTaa306952, the full 1791 bp coding sequence was cloned and shown to encompass 11 exons. The novel protein, named Gigaxonin was shown to contain a BTB domain at its N-terminus and a Kelch domain, composed of 6 Kelch repetitions at its C-terminal end (Bomont et al., 2000; Figure 4A).
Gigaxonin also known as kelch-like protein 16 is a protein that in humans is encoded by the GAN gene. WebApr 12, 2024 · 1 INTRODUCTION. Gigaxonin is a ubiquitously expressed protein encoded by the GAN gene located on human chromosome 16q24.1. 1, 2 The lack or loss of …
Weba, Sequence alignment between human gigaxonin, mayven and ENC-1 proteins, and mouse Keap1 protein. Drosophila kelch protein, which is 59% identical to mayven, is not shown. Identical residues are ...
WebJul 1, 2016 · Gigaxonin functions as an E3 ubiquitin ligase adaptor protein and mediates the ubiquitination and subsequent proteasomal degradation of the targeted proteins [20][21] [22]. Although several 3 ... determining lowest level of significanceWebSep 4, 2002 · By replacing sequences separating the transcription factor binding sites with randomized sequences of the same length, sets of new promoters with different strengths, spanning a 10-fold range of transcriptional activity in cell culture, was obtained. ... which encodes the gigaxonin protein. Gigaxonin is involved in the regulation, turnover, and ... chuo university volleyballWebOct 16, 2005 · Our study defines gigaxonin as a ubiquitin-scaffolding protein that recruits E1 and directs ubiquitin-mediated degradation of MAP1B-LC, a role critical to neuronal … determining lowest vapor pressureWebDec 16, 2008 · PIRSF037037 Kelch-like_protein_gigaxonin 1 hit; PROSITE. View protein in PROSITE; PS50097 BTB 1 hit; Pfam. View protein in Pfam; PF07707 BACK 1 hit; … determining main idea and supporting detailsWebDistantly related proteins sharing a similar domain organization have various functions associated with the cytoskeleton, predicting that gigaxonin is a novel and distinct … chuot logitech tikiWebDec 17, 2012 · The defective protein, gigaxonin, which was first identified in children with a rare and untreatable genetic disease called giant axonal neuropathy (GAN), according to Saleemulla Mahammad, PhD, of ... chuo university cplusWebApr 24, 2014 · The BTB-KELCH protein Gigaxonin plays key roles in sustaining neuron survival and cytoskeleton architecture. Indeed, recessive mutations in the Gigaxonin-encoding gene cause Giant Axonal Neuropathy (GAN), a severe neurodegenerative disorder characterized by a wide disorganization of the Intermediate Filament network. ... The … determining lowest osmotic pressure