Ctgf target
WebMar 18, 2010 · Connective tissue growth factor (CTGF) is a profibrogenic factor that stimulates fibroblast proliferation, cell adhesion, and extracellular matrix production (9,10). The potential role of CTGF in pathological fibrosis has been established , and CTGF has been suggested to be an attractive therapeutic target in some fibrotic diseases . WebSep 11, 2024 · Although the YAP target CTGF was decreased after Ras transformation in MCF10A cells, increased expression is seen after HRas G12V expression in HEK293T cells 25.
Ctgf target
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WebAug 30, 2024 · CTGF expression is increased in renal fibrosis as well as hepatic fibrosis, and a recent study reported CTGF as a new target in renal fibrosis . In addition, autophagy is essential for the maintenance of kidney homeostasis, structure, and function, and dysregulated autophagy contributes to the pathogenesis of various kidney diseases [ 29 ]. WebApr 17, 2024 · Focus on the target genes that affect tumor invasion and metastasis, providing the possibility for the selection of clinical drug treatment targets, to provide some help for a more in-depth study of tumor invasion and migration mechanism and the development of clinical drugs. ... CTGF. Connective tissue growth factor (CTGF) is a …
WebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. Genetic inhibition of CTGF in human melanoma cells is sufficient to … WebCTGF is a direct target of YAP and TEAD. (A) Both YAP and TEAD1 bind to the CTGF promoter. ChIP from MCF10A cells was performed with control IgG, YAP, or TEAD1 antibody as indicated.
WebMar 10, 2024 · Overall, our work suggests a novel function for CTGF as a modulator of cancer metabolism, indicating that CTGF is a potential therapeutic target in TNBC. … WebMar 23, 2024 · As shown in Figure S3C, overexpression of NFATC2 significantly upregulated the expression levels of the target genes of Hippo/YAP signaling pathway (CTGF and Gli2) 18–20 in both HCT-116 and HT-29 cells. Conversely, reduced mRNA expression levels of CTGF and Gli2 were observed in NFATC2-knockdown HCT-116 …
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WebJun 1, 2024 · Current treatment approaches targeting CTGF are summarized and new insights into the identification and validation of selective inhibitors are proposed. … solo leveling crunchyrollWebTransforming growth factor (TGF)-beta regulates diverse biologic activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ECM) synthesis. TGF-beta is believed to be a key mediator of tissue fibrosis as a consequence of ECM accumulation in pathologic … solo leveling high orcsWebJun 1, 2024 · Increasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. The interplay of tumor cells and the tumor microenvironment significantly affects the efficacy of therapeutic agents. The functional importance of CTGF provides an opportunity to disrupt ECM-mediated protection and to target tumors directly. solo leveling cha hae in and sung jin wooWebHerein, we propose that CTGF is a promising cancer therapeutic target that could potentially improve the clinical outcomes of cancer patients. Keywords connective tissue … solo leveling gachaWebMar 6, 2024 · Genetic deletion of CTGF from neurons, in turn, mitigates the TSC-dependent hypomyelination phenotype. These results show that the mechanistic target of rapamycin (mTOR) pathway in neurons regulates CTGF production and secretion, revealing a paracrine mechanism by which neuronal signaling regulates oligodendrocyte maturation … small bedroom colour schemesWebHere, we describe the molecular and biological characteristics of CTGF, its regulation and various functions in the spectrum of development and regeneration to fibrosis. We further … small bedroom cozy grey bedroom decorWebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast … solo leveling chapter