Cholesterol trialist collaboration

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August undefined, 2024

WebThe secretariat of the Cholesterol Treatment Trialists' Collaboration was established to coordinate the prospective meta-analysis. Individual patient data (IPD) were checked for internal consistency and completeness of … WebOct 8, 2005 · Background: Results of previous randomised trials have shown that interventions that lower LDL cholesterol concentrations can significantly reduce the incidence of coronary heart disease (CHD) and other major vascular events in a wide range of individuals. But each separate trial has limited power to assess particular outcomes or …

Recurrent Atherosclerotic Cardiovascular Disease Events …

WebJun 1, 1995 · Cholesterol Treatment Trialists' (CTT) Collaboration. The Cholesterol Treatment Trialists' Collaboration aims to provide reliable information about the effects … WebThe Cholesterol Treatment Trialists’ (CTT) Collaboration conducts meta-analyses of cholesterol intervention trials. It was originally established in 1994 with the aim of … i am frequently asked the question

Efficacy and safety of cholesterol-lowering treatment ... - PubMed

WebJul 1, 2012 · Researchers from the Cholesterol Treatment Trialists' (CTT) Collaboration have argued for maximal lowering of low-density lipoprotein cholesterol (LDL-C) by the … WebFeb 2, 2024 · We found a 12% (RR 0·88, 95% CI 0·85-0·91) proportional reduction in vascular mortality per 1·0 mmol/L reduction in LDL cholesterol, with a trend towards smaller proportional reductions with older age (p trend =0·004), but this trend did not persist after exclusion of the heart failure or dialysis trials (p trend =0·2). Statin therapy had ... WebBaigent C, Blackwell L, Emberson J, et al; Cholesterol Treatment Trialists’ (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010;376(9753):1670-1681.PubMed Google Scholar Crossref i am freezing sweatshirt

Contribution of remnant cholesterol to cardiovascular risk

Cholesterol — Clinical Trial Service Unit

WebFeb 4, 2024 · In the 28 trials of 186,854 participants, 8% (14,483) were >75 years at baseline and median follow-up was 4.9 years. There was a 21% proportional reduction in major CVEs per 1.0 mmol/L reduction in LDL-C, which decreased insignificantly with age and significantly in all age groups. Overall, statin or more intensive statin therapy yielded … WebFeb 2, 2024 · Meta-analyses of individual participant data from 27 randomised trials in the Cholesterol Treatment Trialists' (CTT) Collaboration database indicate that each 1·0 mmol/L reduction in LDL cholesterol with statin therapy reduces the risk of major vascular events by about a fifth, with similar proportional risk reductions among men and women, moments tides lyricsWebApr 10, 2024 · ‘We included 21 statin trials in our analysis. We appraised the quality of these studies and found them to be largely at low risk of bias. We conducted a meta-analysis on 19 of the 21 trials that reported data on all-cause … moments that worth to remember

"WebSep 1, 2024 · This study aimed to assess if information on CAD severity from coronary computed tomography angiography (CTA) can identify patients that benefit most from treating low-density lipoprotein-cholesterol (LDL-C) to American Heart Association/American College of Cardiology (ACC/AHA) and European Society of … " - Cholesterol trialist collaboration

Cholesterol trialist collaboration

Efficacy and safety of LDL-lowering therapy among men and ... - PubMed

WebNov 13, 2010 · We aimed to assess the safety and efficacy of more intensive lowering of LDL cholesterol with statin therapy. Methods: We undertook meta-analyses of … WebSep 8, 2024 · ‘The company (Novartis) used the Cholesterol Treatment Trialist Collaboration (CTT)meta-analyses, which reported change in cardiovascular event risk per1 mmol/l reduction in LDL-C by statin use. The ERG agreed that these analyses were appropriate and noted that earlier versions of this source were used in past NICE …

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WebNational Center for Biotechnology Information WebNov 10, 2024 · For these calculations, we assumed 30% and 22% relative risk reduction of myocardial infarction and atherosclerotic cardiovascular disease, respectively, per 1·0 mmol/L reduction in LDL cholesterol in individuals free of atherosclerotic cardiovascular disease, as observed in the Cholesterol Trialist Collaboration meta-analyses.

WebFeb 19, 2024 · 7 systematic reviews [11-135 randomized controlled trials (RCTs); 18,192-192,977 patients] from the last 5 years. 1-7 Focusing on the most recent (23 RCTs; 154,664 patients x4.3 years). 1 Results statistically significant unless indicated. Any muscle symptoms, statin versus placebo, WebMore recent trials have helped to address important additional questions, such as whether more intensive lowering of cholesterol is beneficial and whether the benefits extend to different patient populations. CTSU’s …

WebAug 28, 2024 · It has been long-recognised, since the Cholesterol Treatment Trialist Collaboration, that the relative risk reduction per unit LDL-cholesterol lowering with statins is less for vascular death than for myocardial infarction or stroke. 1. Cholesterol Treatment Trialists Collaborators WebMay 17, 2012 · The Cholesterol Treatment Trialists' (CTT) Collaboration previously reported meta-analyses of individual data from 170 000 individuals in 21 trials of …

WebNov 27, 2024 · Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort ... as observed in the Cholesterol Trialist Collaboration meta-analyses. 18 Moderate-intensity statin therapy was expected to reduce LDL cholesterol …

WebNov 9, 2010 · 6031 participants were allocated 80 mg simvastatin daily, and 6033 allocated 20 mg simvastatin daily. During a mean follow-up of 6·7 (SD 1·5) years, allocation to 80 mg simvastatin produced an average 0·35 (SE 0·01) mmol/L greater reduction in LDL cholesterol compared with allocation to 20 mg. Major vascular events occurred in 1477 … iamfroggyfreshWebAug 11, 2012 · Background: Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain. Methods: This meta-analysis included individual participant data from 22 trials of statin versus control (n=134,537; mean LDL cholesterol difference 1·08 mmol/L; median follow-up 4·8 years) … moments to remember wedding planner moments to memories 和訳WebSep 23, 2024 · After five years you have gained 0.4 (QALYs) x 5 (years) = 2 QALYs. If the hip replacement operation has cost £10,000. The cost per QALY = £5,000. The cost per QALY obviously goes down if you live longer. That is a very simple example, most calculations become exceedingly complex. i am french in french wordWeba concern in the medical community. In the Cholesterol Trialist Collaboration, lowering LDL cholesterol by 2 mmol/L (78 mg/dL) in 10000 patients with previous symptomatic vascular disease would prevent 1000 major vascular events and cause 5 to 10 ICH.3 Trials in sec-ondary prevention of stroke showed a 1.7-fold relative i am frightened all the timeWebMar 17, 2024 · The orange line represents the 21% major vascular events risk reduction per 1 mmol L −1 (39 mg dL −1) reduction in LDL cholesterol for individuals with baseline coronary heart disease found in statin trials in the Cholesterol Treatment Trialist’ Collaboration meta-analysis. The blue line represents estimated lipoprotein(a) total … i am frightened of dyingWebApr 13, 2024 · Specifically, we calibrated the rate ratio (RR) for ASCVD events associated with a 39 mg/dL reduction in LDL-C from a meta-analysis by the Cholesterol Treatment … i am friend of god chords